3,4-Methylenedioxymethamphetamine (MDMA) Induced Hyperthermia- The Role of Pro-Inflammatory Cytokines
نویسنده
چکیده
The main 3, 4-methylenedioxymethamphetamine (MDMA)-induced adverse effect is disruption of normal thermoregulation leading to life threatening hyperthermia which is exacerbated by high ambient temperature and linked to chronic neurotoxicity [1-3]. Although the focus of the majority of research on MDMA-induced loss of thermoregulation has been on brain serotonergic and dopaminergic systems, results obtained from recent studies suggest that microglial activation and the subsequent release of the pyrogen interleukin-1 could also contribute to these effects [4, 5]. The aim of this study is to extend our understanding of the underlying mechanisms in the brain leading to the disruption of normal thermoregulation. We have examined the effect of interleukin 1 receptor antagonist (IL-1RA) on MDMA-induced hyperthermia and behavioural effects.
منابع مشابه
Chronic stress enhances the corticosterone response and neurotoxicity to +3,4-methylenedioxymethamphetamine (MDMA): the role of ambient temperature.
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